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Smarter Therapies. Better Lives.

next-generation biotherapeutics

Molecule

At Protomer, we believe that the future of medicine lies in smarter medicines, so we built a company to invent them.

We are engineering the next generation of responsive biotherapeutics

Chemist in laboratory

Founded in 2015 and based in Pasadena, California, Protomer is engineering next-generation responsive biotherapeutics that can sense molecular activators in the body. The company’s proprietary chemical biology-based Molecular Evolution of Peptide Sensors (MEPS) platform enables the development of therapeutic peptides and proteins with tunable activity that can be controlled using small molecules.

Protomer has used this approach toward advancing a portfolio of therapeutic candidates, including glucose-responsive insulin receptor agonists that can sense sugar levels in the blood and automatically adjust their activity as needed.

Chemists in laboratory

Work at Protomer

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Our Life at Protomer

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Alborz Mahdavi, PhD

Jack Steele

Ryan Spencer, PhD

Diao Chen, PhD

Sachin Mali, PhD

Julie Sinclair, PhD

Thomas Hoeg-Jensen, PhD

Danielle Sumilang

Ganesh Sable, PhD

Natalie Elmasry

Phillip Kim

Delaney Foo

Tyler Yeomans

Zenas Heng

Newsroom

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The Biotech Startup Reimagining Insulin from the Ground Up
Research
The Biotech Startup Reimagining Insulin from the Ground Up

In 2011, Alborz Mahdavi (PhD ’15) was reading the latest edition of Nature when an ad caught his attention.

06/01/2026
Insulin Innovator
Research
Insulin Innovator

Nearly 10 million people around the world living with type 1 diabetes must perform a daily series of finger pricks, injections, and insulin pump applications in order to manage their…

06/01/2026
Lilly Announces Acquisition of Protomer Technologies
Press
Lilly Announces Acquisition of Protomer Technologies

INDIANAPOLIS, July 14, 2021 /PRNewswire/ — Eli Lilly and Company (NYSE: LLY) today announced the acquisition of Protomer Technologies (“Protomer”), a private biotech company. Protomer’s proprietary peptide- and protein-engineering platform is used to identify…

02/22/2024